GRK 1387/1 „Die integrative Entwicklung von Modellierungs- und Simulationsmethoden für regenerative Systeme“ (GRK dIEM oSIRIS)

Laufzeit

1. Oktober 2006 bis 31. März 2013

Finanzierung

Deutsche Forschungsgemeinschaft (DFG)

Sprecherin

Prof. Dr. rer. nat. habil. Adelinde M. Uhrmacher

Beteiligte Einrichtungen / Fachgebiete

Informatik, Biologie, Medizin

Kurzbeschreibung

Das GRK befasste sich mit Verfahren zur Untersuchung und Modellierung regenerativer Systeme. Das Graduiertenkolleg war stark interdisziplinär angelegt und führte Experten aus den Bereichen der Informatik, der Medizin und der Biologie zusammen.

Angelegt war dIEM oSIRIS mit 13 Stipendiaten und 3 PostDocs auf 6 Jahre, so dass zwei Generationen von Doktoranden jeweils drei Jahre lang in dIEM oSIRIS forschen konnten.

Publikationen

Some publications of the research training group that appeared later than 2011

  • Fiete Haack, Heiko Lemcke, Roland Ewald, Tareck Rharass and Adelinde M. Uhrmacher (2015): Spatio-temporal model of endogenous ROS and raft-dependent Wnt/beta-catenin signaling driving cell fate commitment in human neural progenitor cells. - PLOS Computational Biology, 11(3):e1004106. doi: 10.1371/journal.pcbi.1004106
  • T. Rharass, H. Lemcke, M. Lantow, S.A. Kuznetsov, D.G. Weiss, D. Panáková (2014): Ca2+-mediated mitochondrial reactive oxygen species metabolism augments wnt/β-catenin pathway activation to facilitate cell differentiation. Journal of Biological Chemistry 289: 27937–27951. doi: 10.1074/jbc.M114.573519.
  • C. Mussmann, R. Hübner, M. Trilck, A. Rolfs, and M. J. Frech (2014): HES5 is a key mediator of Wnt-3a-induced neuronal differentiation. Stem Cells Dev. 23, 1328–1339. doi: 10.1089/scd.2013.0557.
  • A Jaeger, J Baake, DG Weiss and R Kriehuber (2013): Glycogen synthase kinase-3beta regulates differentiation-induced apoptosis of human neural progenitor cells. - Int J Dev Neurosci, 31(1):61-68.
  • Mathias John, Hans-Jörg Schulz, Heidrun Schumann, Adelinde M. Uhrmacher and Andrea Unger (2013): Constructing and visualizing chemical reaction networks from pi-calculus models. - Formal Aspects of Computing, 25(5):723-742. doi: 10.1007/s00165-011-0209-0.
  • H. Lemcke, M.L. Nittel, D.G. Weiss, S.A. Kuznetsov (2013): Neuronal differentiation requires a biphasic modulation of gap junctional intercellular communication caused by dynamic changes of connexin43 expression. European Journal of Neuroscience 38: 2218–2228.
  • H. Lemcke, S.A. Kuznetsov (2013): Involvement of connexin43 in the EGF/EGFR signalling during self-renewal and differentiation of neural progenitor cells. Cellular Signalling 25: 2676–2684. doi: 10.1016/j.cellsig.2013.08.030.
  • Y. Schmitz, K. Rateitschak, O. Wolkenhauer (2013): Analysing the impact of nucleo-cytoplasmic shuttling of beta-catenin and its antagonists APC, Axin and GSK3 on Wnt/beta-catenin signalling. Cellular Signalling 25:11, 2210-2221. doi: 10.1016/j.cellsig.2013.07.005.
  • Dagmar Waltemath, Ron Henkel, Robert Hälke, Martin Scharm, Olaf Wolkenhauer (2013): Improving the reuse of computational models through version control. Bioinformatics 29(6): 742-748. doi: 10.1093/bioinformatics/btt018.
  • Clemens Holzhüter, Alexander Lex, Dieter Schmalstieg, Hans-Jörg Schulz, Heidrun Schumann and Marc Streit (2012): Visualizing Uncertainty in Biological Expression Data. - In: Proceedings of the Visualization and Data Analysis VDA'12.
  • Martin Luboschik, Christian Tominski, Arne Bittig, Adelinde M. Uhrmacher and Heidrun Schumann (2012): Towards Interactive Visual Analysis of Microscopic-Level Simulation Data. - In: Proceedings of SIGRAD 2012 – Interactive Visual Analysis of Data.
  • A. Jaeger, J. Baake, D. G. Weiss, R. Kriehuber (2013): Glycogen synthase kinase-3beta regulates differentiation-induced apoptosis of human neural progenitor cells. Int. J. Dev. Neurosci. 31, 61–68. doi: 10.1016/j.ijdevneu.2012.10.005.
  • A. Jaeger, D.G. Weiss, L. Jonas, R. Kriehuber (2012): Oxidative stress-induced cytotoxic and genotoxic effects of nano-sized titanium dioxide particles in human HaCaT keratinocytes. Toxicology 296:27–36. doi: 10.1016/j.tox.2012.02.016.
  • O. Mazemondet, M. John, S. Leye, A. Rolfs, A.M. Uhrmacher (2012): Elucidating the sources of β-catenin dynamics in human neural progenitor cell. Plos One 7: e42792. doi: 10.1371/journal.pone.0042792.

2011

2010

2009

2008

2007

2006